Sphingosine 1-phosphate receptor antagonists
作者： Rolf E. Swenson
DOI:
关键词:
摘要: The present invention relates to sphingosine-1-phosphate (S1P) receptors and compounds of the general formula: that are useful in treatment prevention conditions associated with such receptors. More specifically, synthesis use sphingosine 1-phosphate receptor 2 (S1P ) antagonists that cancer, atherosclerosis, diabetic retinopathy, other inflammatory diseases. Among these diseases could be treated S1P antagonist those characterized by fibrosis including chronic lung disease, kidney liver heart skin as sclerosis/scleroderma. can also used glioblastoma multiforme (brain cancer), pediatric neuroblastoma, cancers.
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