Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development
作者： Kwong-Him To , Sanja Pajovic , Brenda L Gallie , Brigitte L Thériault
关键词: microRNA 、 p14arf 、 Regulation of gene expression 、 Tumor suppressor gene 、 Mdm2 、 Stem cell 、 Biology 、 Carcinogenesis 、 Retinoblastoma 、 Cancer research
摘要: Background Most human cancers show inactivation of both pRB- and p53-pathways. While retinoblastomas are initiated by loss the RB1 tumor suppressor gene, TP53 mutations have not been found. High expression p53-antagonist MDM2 in may compromise p53 surveillance so that selected for retinoblastoma tumorigenesis. We previously showed p14ARF protein, which activates inhibiting MDM2, is low despite high mRNA expression.
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