The molecular balancing act of p16(INK4a) in cancer and aging.
作者： Kyle M. LaPak , Christin E. Burd
DOI: 10.1158/1541-7786.MCR-13-0350
关键词:
摘要: Located on chromosome 9p21.3, p16INK4a seems lost amongst a cluster of neighboring tumor suppressor genes. While best known for inhibiting cyclin dependent kinase (CDK) activity, is not one trick pony. Long term expression pushes cells to enter senescence, an irreversible cell cycle arrest that prevents the growth would-be cancer cells, but also contributes aging. Loss most frequent events in human tumors and allows pre-cancerous lesions bypass senescence. Therefore, precise regulation essential tissue homeostasis, maintaining tight balance between suppression Here, we outline pathways required proper highlight critical functions cancer, aging physiology make this gene special.
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