Principles and mechanisms of peri-implant soft tissue healing.
作者： Stefan Schultze-Mosgau , Markus B Blatz , Falk Wehrhan , Karl Andreas Schlegel , Michael Thorwart
DOI:
关键词: Pathology 、 Implant 、 Osseointegration 、 Regeneration (biology) 、 Cytokine 、 Soft tissue 、 Medicine 、 Oral mucosa 、 Wound healing 、 Fibrosis
摘要: The long-term clinical and esthetic success of implant-supported restorations is determined by osseointegration optimal remodeling peri-implant soft tissues. Complications soft-tissue management are often caused fibrotic regeneration oral mucosa after multiple surgical procedures. Knowledge the proliferative processes in wound healing necessary to attain adequate conditions. Successful reconstruction tissues feasible even conditions when appropriate techniques selected. pleiotropic cytokine TGF-beta involved regulation all phases tissue remodeling. isoform TGF-beta1 a associated with development tissue. Overexpression causes scarring fibrosis, results limited intraoral management. Experimental therapeutic approaches neutralizing antibodies block resulted less reduction fibrosis. Further molecular biologic research cell-matrix-cytokine interactions will provide highly specific antifibrotic future.
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