Enhanced expression of transforming growth factor-beta type I and type II receptors in wound granulation tissue and hypertrophic scar.

摘要: In the present study we have analyzed and compared, by immunohistochemistry in situ hybridization, expression pattern of R4/ALK5 transforming growth factor (TGF)-beta type I receptor (RI) TGF-beta II (RII) normal human skin, wounded skin at various stages during transition wound granulation tissue to scar, long-persisting post-burn hypertrophic scars. RI RII was clearly visible epidermis, epidermal appendages, vascular cells, although only a small number dermal fibroblasts revealed detectable levels expression. contrast, showed strong both types, normal-healing excisional wounds their density decreased remodeling. However, scars, RI- RII-overexpressing were found high densities up 20 months after injury. From these findings suggest that repair process deep involves transformation subset fibroblastic cells toward an increased responsiveness transient accumulation site. addition, our provides evidence excessive scarring is associated with failure eliminate receptor-overexpressing remodeling, which leads persistent autocrine, positive feedback loop results over-production matrix proteins subsequent fibrosis.