Enhancement of Liver Microsome Epoxide Hydratase Activity in Rodents by Treatment with 2(3)-tert-Butyl-4-hydroxyanisole

摘要: Administration of the antioxidant 2(3)- tert -butyl-4-hydroxyanisole (BHA) in diet caused a marked increase specific activity epoxide hydratase (EC 4.2.1.63) hepatic microsomes CD-1 mice. The increases activities produced by BHA were far greater (11-fold) than those administration well-known enzyme inducers such as 3-methylcholanthrene, phenobarbital, and Aroclor 1254 (2- to 3-fold). near-maximal was observed after feeding for 3 days. When administered gastric intubation, level only 75% that attained diet. treatment Sprague-Dawley rats not pronounced (<3-fold)