Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography

摘要: Surgical treatment of breast cancer aims to identify and remove all malignant tissue. Intraoperative assessment tumor margins is, however, not exact; thus, re-excision is frequently needed, or excess normal tissue removed. Imaging methods applicable intraoperatively could help reduce rates whilst minimizing removal healthy Optical coherence elastography (OCE) has been proposed for use in breast-conserving surgery; intraoperative interpretation complex OCE images may prove challenging. Observations on multiple length scales, by OCE, ultrasound elastography, atomic force microscopy, have shown an increase the mechanical heterogeneity tumors compared In this study, a micro-scale index introduced used form maps from scans 10 ex vivo human samples. Through comparison optical tomography images, corresponding histology, possess higher than benign The map simplifies contrast between stroma tissue, facilitating rapid identification possible areas malignancy, which important step towards margin using OCE. (Figure presented.).