Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography.

摘要: Probing the mechanical properties of tissue on microscale could aid in identification diseased tissues that are inadequately detected using palpation or current clinical imaging modalities, with potential to guide medical procedures such as excision breast tumours. Compression optical coherence elastography (OCE) maps strain spatial resolution and can delineate microstructural features within tissues. However, without a measure locally applied stress, provides only qualitative indication properties. To overcome this limitation, we present quantitative micro-elastography, which combines compression OCE compliant stress sensor image elasticity. The consists layer translucent silicone well-characterized stress-strain behaviour. measured is used estimate two-dimensional distribution sample surface. Elasticity determined by dividing sample. We show quantification elasticity improve ability distinguish between tissues, thereby extending for inter-sample comparison longitudinal studies validate technique tissue-mimicking phantoms demonstrate map freshly excised malignant benign human