Solid base catalyzed highly efficient N-alkylation of amines with alcohols in a solvent-free system
作者： X.-H. Lu , Y.-W. Sun , X.-L. Wei , C. Peng , D. Zhou
DOI: 10.1016/J.CATCOM.2014.06.020
关键词: Benzyl alcohol 、 Sodium hydroxide 、 Transition metal 、 Organic chemistry 、 Catalysis 、 Solvent free 、 Selectivity 、 Chemistry 、 Aniline 、 Alkylation
摘要: Abstract Different from any other catalytic systems containing transition metals and additives, sodium hydroxide itself was found to be a unique effective catalyst for the solvent-free synthesis of secondary amines via N-alkylation with alcohols. For reaction aniline benzyl alcohol, 99.6 mol% conversion 99.5% selectivity product were achieved under optimal conditions. Also, high could acquired N-alkylations various alcohols, implying universality this methodology. Mechanistic studies revealed that novel most possibly proceeds base-catalyzed mechanism.
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