Green and Scalable Aldehyde-Catalyzed Transition Metal-Free Dehydrative N-Alkylation of Amides and Amines with Alcohols
作者： Qing Xu , Qiang Li , Xiaogang Zhu , Jianhui Chen
关键词: Catalysis 、 Alkylation 、 Organic chemistry 、 Chemistry 、 Alcohol 、 Aldehyde 、 Transition metal 、 Dehydrogenation
摘要: In contrast to the borrowing hydrogen-type N-alkylation reactions, in which alcohols were activated by transition metal-catalyzed anaerobic dehydrogenation, addition of external aldehydes was accidentally found be a simple and effective protocol for alcohol activation. This interesting finding subsequently led an efficient green, practical scalable aldehyde-catalyzed metal-free dehydrative method variety amides, amines, alcohols. Mechanistic studies revealed that this reaction most possibly proceeds via but relay race mechanism.
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