Sialochemistry and cortisol levels in patients with Sjogren's syndrome.

摘要: Oral Diseases (2012) 18, 255–259 Objectives:  (i) To determine whether salivary cortisol and electrolyte levels differ between patients with Sjogren’s syndrome (SjS) healthy individuals. (ii) assess correlations whole-saliva some clinical manifestations in SjS. Methods:  A total of 24 women (mean age 49.3 ± 9.8) served as controls (C) vis-a-vis 17 SjS 55.5 ± 15.7). Salivary concentration was determined, sialochemistry analysis performed. Results:  Significantly lower saliva flow rates higher chloride (Cl−), potassium (K+), Ca2+ were found the group. No significant differences or other parameters, including sodium (Na+), magnesium (Mg2+), phosphate (−), urea (U), levels. Conclusion:  Increased whole-salivary output Cl− K+ may reflect release from apoptotic rests acinar cells after secondary necrosis. Normal Na+, Mg2+, − argue against effect, deranged tubular function (mineralocorticosteroid) effect cause for these findings. probably leakage plasma through injured oral mucosa SjS. In spite disease-associated stress, cortisol, a stress biomarker, not increased, suggesting insufficient hypothalamus–pituitary–adrenal (HPA) axis response and/or local consumption by lymphocyte infiltrates.