Fibroblast growth factor signaling in development of the cerebral cortex

摘要: Despite substantial and exciting recent progress in our understanding of developmental processes the cerebral cortex, there is still much to be learned about molecular cellular mechanisms that account for formation cortical structures, turn, how regulation these linked functions behaviors animals humans. Fibroblast growth factors (FGFs) are a classic family important neural development whose structures signaling have been well-studied molecularly biochemically. Recent advances revealed their diverse but specific patterning neurogenesis during development, as evidenced by multiple experimental approaches using vivo models. Importantly, changes FGF shown influence structure function cortex well animal behavior, implicated disorders nervous system intellectual For example, disturbance pathways has pathogenesis autism spectrum disorders. Experimental models with altered due perturbations present unique opportunity whereby underlie behavior can directly studied each other.