The effect of a 72-h fast on plasma levels of pituitary, adrenal, thyroid, pancreatic and gastrointestinal hormones in healthy men and women.

摘要: Seventeen human subjects fasted without electrolyte replacement for 3 days and hormone levels were measured before, during after the fast. Immediate consequences of fasting state in healthy include a marked increase plasma cortisol. ACTH, beta-endorphin, beta-lipotrophic hormone, adrenaline, noradrenaline dopamine. Levels all these hormones much greater on first morning fast than post-prandial state, even though glucose level was no lower that observed before began. A clear fall TSH tri-iodothyronine (T3) observed, but thyroxine did not change significantly. Insulin fell whereas proinsulin fast, they rise markedly upon re-feeding. An GH particularly apparent male subjects, also seen females when evening samples compared. Pancreatic glucagon showed modest again refeeding; total rose as proceeded, increased gastrin peptide YY remained low Plasma unchanged. The following closely correlated: cortisol with T3 log10 TSH, dopamine noradrenaline, (negatively, fast) pancreatic glucose.