The effects of fasting and refeeding on adrenal cortex morphometry and serum concentrations of ACTH and corticosterone in young and old male rats
作者： Z Kmiec , A Mysliwski , G Kotlarz , L Pokrywka
DOI:
关键词: Adrenal cortex 、 Adrenal gland 、 Internal medicine 、 Reticular connective tissue 、 Corticosterone 、 Endocrinology 、 Hormone 、 Stimulation 、 Ageing 、 Homeostasis 、 Biology
摘要: The impairment of homeostatic mechanisms in ageing becomes often apparent upon physiological or pathological stimulation. We have previously shown that fasting and refeeding revealed the existence age-related changes carbohydrate lipid metabolism. Because fuel metabolism is partially controlled by corticosteroids we decided to determine effects on adrenal gland morphometry, ACTH, corticosterone serum levels young (5 mo) (20 old male Wistar rats. Fasting for 48 h did not change ACTH both age groups. level after 24 However, old, but animals, resulted decrease concentration. relative weight (% body weight) significantly with (p=0.05). induced rats ones increase weight, volume reticular zone. Refeeding reduced volume, fascicular zone decreased total due a decline volumes zones. In It concluded ageing-dependent secretion corticosterone, key hormone prolonged stress response.
jpp.krakow.pl 参考文章(13)
Steven W. J. Lamberts, Endocrinology of Aging Humana Press. pp. 419- 427 ,(2005) , 10.1007/978-1-59259-829-8_28
A. G. Dulloo, J. Seydoux, L. Girardier, Role of corticosterone in adaptive changes in energy expenditure during refeeding after low calorie intake. American Journal of Physiology-endocrinology and Metabolism. ,vol. 259, ,(1990) , 10.1152/AJPENDO.1990.259.5.E658
Mary Ellen Bligh, Marie B. DeStefano, Susan K. Kramlik, Larry W. Douglass, Paul Dubuc, Thomas W. Castonguay, Adrenal modulation of the enhanced fat intake subsequent to fasting. Physiology & Behavior. ,vol. 48, pp. 373- 381 ,(1990) , 10.1016/0031-9384(90)90331-W
S. F. Beer, P. M. M. Bircham, S. R. Bloom, P. M. Clark, C. N. Hales, C. M. Hughes, C. T. Jones, D. R. Marsh, P. R. Raggatt, A. L. R. Findlay, The effect of a 72-h fast on plasma levels of pituitary, adrenal, thyroid, pancreatic and gastrointestinal hormones in healthy men and women. Journal of Endocrinology. ,vol. 120, pp. 337- 350 ,(1989) , 10.1677/JOE.0.1200337
Gary W. Britton, Samuel Rotenberg, Richard C. Adelman, Impaired regulation of corticosterone levels during fasting in aging rats. Biochemical and Biophysical Research Communications. ,vol. 64, pp. 184- 188 ,(1975) , 10.1016/0006-291X(75)90236-3
S F Akana, A M Strack, E S Hanson, M F Dallman, Regulation of Activity in the Hypothalamo-Pituitary- Adrenal Axis Is Integral to a Larger Hypothalamic System that Determines Caloric Flow* Endocrinology. ,vol. 135, pp. 1125- 1134 ,(1994) , 10.1210/ENDO.135.3.8070356
Piera Rebuffat, Anna S. Belloni, Stefano Rocco, Paola G. Andreis, Giuliano Neri, Ludwik K. Malendowicz, Giuseppe Gottardo, Giuseppina Mazzocchi, Gastone G. Nussdorfer, The effects of ageing on the morphology and function of the zonae fasciculata and reticularis of the rat adrenal cortex. Cell and Tissue Research. ,vol. 270, pp. 265- 272 ,(1992) , 10.1007/BF00328012
Henrique de Almeida, Maria C Magalhães, Manuel M Magalhães, Age-related changes in the inner zone of the adrenal cortex of the rat—a morphologic and biochemical study Mechanisms of Ageing and Development. ,vol. 105, pp. 1- 18 ,(1998) , 10.1016/S0047-6374(98)00099-2
Rexford S. Ahima, Daniel Prabakaran, Christos Mantzoros, Daqing Qu, Bradford Lowell, Eleftheria Maratos-Flier, Jeffrey S. Flier, Role of leptin in the neuroendocrine response to fasting Nature. ,vol. 382, pp. 250- 252 ,(1996) , 10.1038/382250A0
A. Mysliwski, Z. Kmiec, Effect of aging on glycogen synthesis in liver of starved-refed rats Archives of Gerontology and Geriatrics. ,vol. 14, pp. 85- 92 ,(1992) , 10.1016/0167-4943(92)90009-S