Optimization and anticancer activity in vitro and in vivo of baohuoside I incorporated into mixed micelles based on lecithin and Solutol HS 15
作者： Hong-mei Yan , Jie Song , Zhen-hai Zhang , Xiao-bin Jia
DOI: 10.3109/10717544.2015.1120365
关键词: In vitro 、 Bioinformatics 、 In vivo 、 Targeted drug delivery 、 Drug 、 Medicine 、 IC50 、 Lecithin 、 Pharmacology 、 A549 cell 、 Micelle
摘要: Baohuoside I, extracted from the Herba epimedii, is an effective but a poorly soluble antitumor drug. To improve its solubility, formulation of baohuoside I-loaded mixed micelles with lecithin and Solutol HS 15 (BLSM) has been performed in this study. We systematic comparative evaluation antiproliferative effect, cellular uptake, efficacy, vivo tumor targeting these using non-small cell lung cancer (NSCLC) A549 cells. Results showed that obtained have mean particle size around 62.54 nm, was narrowly distributed. With improved BLSM displayed more potent action on lines than I; half-maximal inhibitory concentration (IC50) 6.31 versus 18.28 µg/mL, respectively. The efficacy test nude mice exhibited significantly higher activity against NSCLC lesser toxic effects normal tissues. imaging study for demonstrated achieved targeted drug delivery. Therefore, might be potential formulation.
sci-hub.se 参考文章(40)
Xiaobin Tan, Yan Chen, Chenyi Fan, Xiaobin Jia, Ming Hu, Absorption and metabolism of flavonoids in Herba Epimedii via rat intestinal perfusion model. China journal of Chinese materia medica. ,vol. 34, pp. 2928- 2931 ,(2009)
Manu Smriti Singh, Alf Lamprecht, P-glycoprotein inhibition of drug resistant cell lines by nanoparticles Drug Development and Industrial Pharmacy. ,vol. 42, pp. 325- 331 ,(2016) , 10.3109/03639045.2015.1054396
Kaili Hu, Jingwei Li, Yehong Shen, Wei Lu, Xiaoling Gao, Qizhi Zhang, Xinguo Jiang, Lactoferrin-conjugated PEG-PLA nanoparticles with improved brain delivery: in vitro and in vivo evaluations. Journal of Controlled Release. ,vol. 134, pp. 55- 61 ,(2009) , 10.1016/J.JCONREL.2008.10.016
Xin Jin, Zhen-Hai Zhang, E. Sun, Xiao-Bin Tan, Fen-Xia Zhu, Xiao-Bin Jia, A novel drug-phospholipid complex loaded micelle for baohuoside I enhanced oral absorption: in vivo and in vivo evaluations. Drug Development and Industrial Pharmacy. ,vol. 39, pp. 1421- 1430 ,(2013) , 10.3109/03639045.2012.719234
Jun Fang, Hideaki Nakamura, Hiroshi Maeda, The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect Advanced Drug Delivery Reviews. ,vol. 63, pp. 136- 151 ,(2011) , 10.1016/J.ADDR.2010.04.009
Praveen Potluri, Guru V. Betageri, Mixed-micellar proliposomal systems for enhanced oral delivery of progesterone. Drug Delivery. ,vol. 13, pp. 227- 232 ,(2006) , 10.1080/10717540500395007
A.B. Ballinger, D. Forget, A. Le Brun, M.J.G. Farthing, An Evaluation of the Safety of Mixed Micelles in Healthy Subjects Journal of Parenteral and Enteral Nutrition. ,vol. 20, pp. 110- 112 ,(1996) , 10.1177/0148607196020002110
Yan-Qiu Liu, Qian-Xu Yang, Meng-Chun Cheng, Hong-Bin Xiao, Synergistic inhibitory effect of Icariside II with Icaritin from Herba Epimedii on pre-osteoclastic RAW264.7 cell growth. Phytomedicine. ,vol. 21, pp. 1633- 1637 ,(2014) , 10.1016/J.PHYMED.2014.07.016
Xiufeng Ji, Yu Gao, Lingli Chen, Zhiwen Zhang, Yihui Deng, Yaping Li, Nanohybrid systems of non-ionic surfactant inserting liposomes loading paclitaxel for reversal of multidrug resistance International Journal of Pharmaceutics. ,vol. 422, pp. 390- 397 ,(2012) , 10.1016/J.IJPHARM.2011.10.003
Barbora Orlikova, José C.J.M.D.S. Menezes, Seungwon Ji, Shrivallabh P. Kamat, José A.S. Cavaleiro, Marc Diederich, Methylenedioxy flavonoids: assessment of cytotoxic and anti-cancer potential in human leukemia cells. European Journal of Medicinal Chemistry. ,vol. 84, pp. 173- 180 ,(2014) , 10.1016/J.EJMECH.2014.07.003