P-glycoprotein inhibition of drug resistant cell lines by nanoparticles
作者： Manu Smriti Singh , Alf Lamprecht
DOI: 10.3109/03639045.2015.1054396
关键词:
摘要: AbstractSeveral pharmaceutical excipients are known for their ability to interact with cell membrane lipids and reverse the phenomenon of multidrug resistance (MDR) in cancer. Interestingly, many act as stabilizers key ingredients a variety nano-formulations. In this study, representatives ionic non-ionic were used surface active agents nanoparticle (NP) formulations utilize MDR reversing potential. In-vitro assays performed elucidate particle–cell interaction accumulation P-glycoprotein (P-gp) substrates-rhodamine-123 calcein AM, highly drug resistant glioma lines. Chemosensitization achieved using NPs equivalent dose free was assessed co-administered anti-cancer doxorubicin. Among used, surfactant, Cremophor® EL, cationic cetyltrimethylammonuium bromide (CTAB), demonstrated highest P-gp modulatory activity both solution form (up 7-...
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