Drug-Metabolizing Ability of Molybdenum Hydroxylases
作者： Shigeyuki Kitamura , Kazumi Sugihara , Shigeru Ohta
DOI: 10.2133/DMPK.21.83
关键词: Oxidase test 、 Xanthine dehydrogenase 、 Sulfoxide 、 Aldehyde oxidase 、 Biochemistry 、 Molybdenum 、 Metabolism 、 Chemistry 、 Drug 、 Nitro
摘要: Molybdenum hydroxylases, which include aldehyde oxidase and xanthine oxidoreductase, are involved in the metabolism of some medicines humans. They exhibit activity towards various heterocyclic compounds aldehydes. The liver cytosol mammals also exhibits a significant reductase toward nitro, sulfoxide, N-oxide other moieties, catalyzed by oxidase. There is considerable variability mammals: humans show highest activity, rats mice low dogs have no detectable activity. On hand, oxidoreductase present widely among species. Interindividual variation Drug-drug interactions associated with potential clinical significance. Drug metabolizing ability molybdenum hydroxylases described this review.
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