Species differences in enantioselective 2-oxidations of RS-8359, a selective and reversible MAO-A inhibitor, and cinchona alkaloids by aldehyde oxidase.

作者： Kunio Itoh , Mayumi Yamamura , Wataru Takasaki , Takamitsu Sasaki , Akiko Masubuchi

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摘要: The 2-oxidation activity on the pyrimidine ring of RS-8359, a MAO-A inhibitor, is major metabolic pathway catalysed by aldehyde oxidase. This study investigated species differences in using liver cytosolic fractions from rats, mice, guinea-pigs, rabbits, dogs, monkeys and humans. Vmax/Km value for (S)-enantiomer RS-8359 was extremely high humans, moderate low rats mice. Dogs were deficient activity. (R)-enantiomer only oxidized at very rate not mice rabbits. Thus, marked enantioselectivity obvious RS-8359. vitro results good accordance with previously reported vivo excretion data 2-keto metabolite non-detectable plasma concentrations humans after administration racemic Enantioselectivity also observed oxidation cinchona alkaloids Among four studied, cinchonidine, which has no substituents 6-hydroxy group but bears (8S,9R)-configurations, highest. As opposed to (S)-enantiomer, an catalytic cinchonidine confirmed or Rabbit oxidase suggested have characteristic properties around active site. Copyright © 2006 John Wiley & Sons, Ltd.

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Species differences in enantioselective 2-oxidations of RS-8359, a selective and reversible MAO-A inhibitor, and cinchona alkaloids by aldehyde oxidase.

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Species differences in enantioselective 2-oxidations of RS-8359, a selective and reversible MAO-A inhibitor, and cinchona alkaloids by aldehyde oxidase.

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