Properties of 130 kDa subunit of monkey aldehyde oxidase.

作者: Tasuku Asakawa , Kunio Itoh , Mayuko Adachi , Kouichi Hoshino , Nobuaki Watanabe

DOI: 10.1248/BPB.31.380

关键词:

摘要: We previously demonstrated the existence of a minor 130 kDa subunit in sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE)/Western blot analysis monkey liver cytosol and expressed aldehyde oxidase (AO) Escherichia coli. In contrast, was not observed rat AO. current study, properties were investigated from viewpoint species differences presence AO activity. Monkey with His-tag at N- C-terminus expressed, immunoanalyzed anti-AO anti-His-tag antisera. The results revealed that produced by cleavage N-terminal side 150 subunit. point shown to be located between 188Leu 189Pro Edman degradation method. two amino acids related are contained linkage 2Fe-2S FAD domains human monkey, but mouse. As fact, mouse, suggesting might one reason difference formation However, is associated activity, because loss cluster domain essential for exertion

参考文章(27)
Christine Beedham, The role of non—P450 enzymes in drug oxidation. Pharmacy World & Science. ,vol. 19, pp. 255- 263 ,(1997) , 10.1023/A:1008668913093
Philip J. Sherratt, John D. Hayes, Glutathione S-transferases Enzyme Systems that Metabolise Drugs and Other Xenobiotics. pp. 319- 352 ,(2002) , 10.1002/0470846305.CH9
Kunio Itoh, Mayumi Yamamura, Wataru Takasaki, Takamitsu Sasaki, Akiko Masubuchi, Yorihisa Tanaka, Species differences in enantioselective 2-oxidations of RS-8359, a selective and reversible MAO-A inhibitor, and cinchona alkaloids by aldehyde oxidase. Biopharmaceutics & Drug Disposition. ,vol. 27, pp. 133- 139 ,(2006) , 10.1002/BDD.494
TOMIHISA YOKOYAMA, TOSHIO KARUBE, NOBUYOSHI IWATA, Comparative studies of the effects of RS-8359 and safrazine on monoamine oxidase in-vitro and in-vivo in mouse brain. Journal of Pharmacy and Pharmacology. ,vol. 41, pp. 32- 36 ,(2011) , 10.1111/J.2042-7158.1989.TB06324.X
H. Miura, M. Naoi, D. Nakahara, T. Ohta, T. Nagatsu, Changes in monoamine levels in mouse brain elicited by forced-swimming stress, and the protective effect of a new monoamine oxidase inhibitor, RS-8359. Journal of Neural Transmission. ,vol. 94, pp. 175- 187 ,(1993) , 10.1007/BF01277023
Shigeyuki Kitamura, Kazumi Sugihara, Keiko Nakatani, Shigeru Ohta, Toshinari Oh-Hara, Shin-Ichi Ninomiya, Carol Green, Charles Tyson, Variation of hepatic methotrexate 7-hydroxylase activity in animals and humans. Iubmb Life. ,vol. 48, pp. 607- 611 ,(1999) , 10.1080/713803569
K. Itoh, M. Yamamura, S. Muramatsu, K. Hoshino, A. Masubuchi, T. Sasaki, Y. Tanaka, Stereospecific oxidation of the (S)-enantiomer of RS-8359, a selective and reversible monoamine oxidase A (MAO-A) inhibitor, by aldehyde oxidase. Xenobiotica. ,vol. 35, pp. 561- 573 ,(2005) , 10.1080/00498250500202106
R. M. Wright, G. M. Vaitaitis, C. M. Wilson, T. B. Repine, L. S. Terada, J. E. Repine, cDNA cloning, characterization, and tissue-specific expression of human xanthine dehydrogenase/xanthine oxidase. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 10690- 10694 ,(1993) , 10.1073/PNAS.90.22.10690
Mami KUROSAKI, Silvia DEMONTIS, Maria Monica BARZAGO, Enrico GARATTINI, Mineko TERAO, Molecular cloning of the cDNA coding for mouse aldehyde oxidase: tissue distribution and regulation in vivo by testosterone. Biochemical Journal. ,vol. 341, pp. 71- 80 ,(1999) , 10.1042/BJ3410071
C. GERALDINE M. JORDAN, MOHAMMED R. RASHIDI, HUSSAIN LALJEE, STEPHEN E. CLARKE, JOHN E. BROWN, CHRISTINE BEEDHAM, Aldehyde oxidase-catalysed oxidation of methotrexate in the liver of guinea-pig, rabbit and man. Journal of Pharmacy and Pharmacology. ,vol. 51, pp. 411- 418 ,(2010) , 10.1211/0022357991772619