Variation of hepatic methotrexate 7-hydroxylase activity in animals and humans.
作者： Shigeyuki Kitamura , Kazumi Sugihara , Keiko Nakatani , Shigeru Ohta , Toshinari Oh-Hara
DOI: 10.1080/713803569
关键词:
摘要: This study deals with individual and species variations in the converting activity of methotrexate (MTX) to 7-hydroxymethotrexate animals humans. When MTX 7-hydroxylase was assayed six human liver cytosols, a 48-fold range intersubject variation observed. The were correlated concentrations aldehyde oxidase subjects benzaldehyde as substrate. Species differences also highest rabbits, followed by rats, hamsters, monkeys but undetectable dogs. Strain based on observed rats mice. results suggest that functions livers humans, are due amount present.
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