Construction and expression of mutant cDNAs responsible for genetic polymorphism in aldehyde oxidase in Donryu strain rats.
作者： Mayuko Adachi , Kunio Itoh , Akiko Masubuchi , Nobuaki Watanabe , Yorihisa Tanaka
DOI: 10.5483/BMBREP.2007.40.6.1021
关键词:
摘要: We demonstrated the genetic polymorphism of aldehyde oxidase (AO) in Donryu strain rats: ultrarapid metabolizer (UM) with nucleotide mutation (377G, 2604C) coding for amino acid substitution (110Gly, 852Val), extensive (EM) (377G/A, 2604C/T) (110Gly/Ser, 852Val/Ala), and poor (PM) (377A, 2604T) (110Ser, 852Ala), respectively. The results suggested that 377G > A and/or 2604C T should be responsible polymorphism. In this study, we constructed an E. coli expression system four types AO cDNA including Mut-1 Mut-2 as well naturally existing sequences UM PM order to clarify which one is showed almost same high low activity groups, Thus, study mutant directly revealed A, but not T, will play a critical role rats. reason cause was discussed.
koreascience.or.kr参考文章(23)
Christine Beedham, The role of non—P450 enzymes in drug oxidation. Pharmacy World & Science. ,vol. 19, pp. 255- 263 ,(1997) , 10.1023/A:1008668913093
Salome Gluecksohn-Waelsch, Paul Greengard, Gertrude P. Quinn, Luz S. Teicher, Genetic Variations of an Oxidase in Mammals Journal of Biological Chemistry. ,vol. 242, pp. 1271- 1273 ,(1967) , 10.1016/S0021-9258(18)96174-0
Kunio Itoh, Mayumi Yamamura, Wataru Takasaki, Takamitsu Sasaki, Akiko Masubuchi, Yorihisa Tanaka, Species differences in enantioselective 2-oxidations of RS-8359, a selective and reversible MAO-A inhibitor, and cinchona alkaloids by aldehyde oxidase. Biopharmaceutics & Drug Disposition. ,vol. 27, pp. 133- 139 ,(2006) , 10.1002/BDD.494
TOMIHISA YOKOYAMA, TOSHIO KARUBE, NOBUYOSHI IWATA, Comparative studies of the effects of RS-8359 and safrazine on monoamine oxidase in-vitro and in-vivo in mouse brain. Journal of Pharmacy and Pharmacology. ,vol. 41, pp. 32- 36 ,(2011) , 10.1111/J.2042-7158.1989.TB06324.X
H. Miura, M. Naoi, D. Nakahara, T. Ohta, T. Nagatsu, Changes in monoamine levels in mouse brain elicited by forced-swimming stress, and the protective effect of a new monoamine oxidase inhibitor, RS-8359. Journal of Neural Transmission. ,vol. 94, pp. 175- 187 ,(1993) , 10.1007/BF01277023
Shigeyuki Kitamura, Kazumi Sugihara, Keiko Nakatani, Shigeru Ohta, Toshinari Oh-Hara, Shin-Ichi Ninomiya, Carol Green, Charles Tyson, Variation of hepatic methotrexate 7-hydroxylase activity in animals and humans. Iubmb Life. ,vol. 48, pp. 607- 611 ,(1999) , 10.1080/713803569
Christine Beedham, Jeffrey J. Miceli, R. Scott Obach, Ziprasidone Metabolism, Aldehyde Oxidase, and Clinical Implications Journal of Clinical Psychopharmacology. ,vol. 23, pp. 229- 232 ,(2003) , 10.1097/01.JCP.0000084028.22282.F2
K. Itoh, M. Yamamura, S. Muramatsu, K. Hoshino, A. Masubuchi, T. Sasaki, Y. Tanaka, Stereospecific oxidation of the (S)-enantiomer of RS-8359, a selective and reversible monoamine oxidase A (MAO-A) inhibitor, by aldehyde oxidase. Xenobiotica. ,vol. 35, pp. 561- 573 ,(2005) , 10.1080/00498250500202106
N. Guerrieri, P. Cerletti, M. De Vincentiis, A. Salvati, S. Scippa, Vanadium inhibition of serine and cysteine proteases. Comparative Biochemistry and Physiology A-molecular & Integrative Physiology. ,vol. 122, pp. 331- 336 ,(1999) , 10.1016/S1095-6433(99)00014-8
C. GERALDINE M. JORDAN, MOHAMMED R. RASHIDI, HUSSAIN LALJEE, STEPHEN E. CLARKE, JOHN E. BROWN, CHRISTINE BEEDHAM, Aldehyde oxidase-catalysed oxidation of methotrexate in the liver of guinea-pig, rabbit and man. Journal of Pharmacy and Pharmacology. ,vol. 51, pp. 411- 418 ,(2010) , 10.1211/0022357991772619