Deamination of norepinephrine, dopamine, and serotonin by type A monoamine oxidase in discrete regions of the rat brain and inhibition by RS-8359.
作者： Yoshihiro Kumagae , Yoshiki Matsui , Nobuyoshi Iwata
DOI: 10.1254/JJP.55.121
关键词: Internal medicine 、 Moclobemide 、 Monoamine oxidase A 、 Homovanillic acid 、 Biochemistry 、 Endocrinology 、 Serotonin 、 Catecholamine 、 Monoamine neurotransmitter 、 Dopamine 、 Chemistry 、 Monoamine oxidase inhibitor
摘要: Levels of monoamines and their metabolites were determined in the cortex, hippocampus, striatum rats killed by microwave irradiation. Moclobemide (20 mg/kg, p.o.) clorgyline (10 p.o.), type A monoamine oxidase (MAO-A) inhibitors, increased levels normetanephrine (NM) 3-methoxytyramine (3MT) decreased those 3, 4-dihydroxyphenylacetic acid (DOPAC), homovanillic (HVA), 5-hydroxyindoleacetic (5HIAA) almost all three regions. Deprenyl a B inhibitor, however, little affected metabolite The maximum effects RS-8359 obtained at 2 to 6 hr after administration, when norepinephrine (NE), NM, 3MT, serotonin (5HT) regions dopamine (DA) increased, while DOPAC HVA decreased. had returned normal 20 administration. Dose-dependency on was observed doses up 30 mg/kg (p.o.) 1 In conclusion, NE, DA, 5HT are exclusively or preferentially deaminated MAO-A rats, exhibits reversible inhibitory action tested vivo.
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