Heredity mode of genetic polymorphism in aldehyde oxidase activity in Donryu strain rats.

作者: M. Adachi , K. Itoh , H. Abe , Y. Tanaka

DOI: 10.1080/00498250701708513

关键词:

摘要: Donryu strain rats show genetic polymorphisms in the aldehyde oxidase gene, resulting phenotypic expression of ultrarapid metabolizers with homozygous nucleotide sequences (337G, 2604C), extensive heterozygous (377G/A, 2604C/T), and poor (377A, 2604T). In mating experiments ratio number metabolizers, F1 generation from F0 male female was roughly 0.6 : 1.5 1, converged to approximately 1 2 F2 rats. On contrary, all or had genotypes phenotypes. The completely agreed with...

参考文章(26)
Christine Beedham, The role of non—P450 enzymes in drug oxidation. Pharmacy World & Science. ,vol. 19, pp. 255- 263 ,(1997) , 10.1023/A:1008668913093
Russ Hille, Takeshi Nishino, Flavoprotein structure and mechanism. 4. Xanthine oxidase and xanthine dehydrogenase. The FASEB Journal. ,vol. 9, pp. 995- 1003 ,(1995) , 10.1096/FASEBJ.9.11.7649415
Kazumi Sugihara, Shigeyuki Kitamura, Kiyoshi Tatsumi, Toshimasa Asahara, Kiyohiko Dohi, Differences in aldehyde oxidase activity in cytosolic preparations of human and monkey liver IUBMB Life. ,vol. 41, pp. 1153- 1160 ,(1997) , 10.1080/15216549700202241
Kunio Itoh, Mayumi Yamamura, Wataru Takasaki, Takamitsu Sasaki, Akiko Masubuchi, Yorihisa Tanaka, Species differences in enantioselective 2-oxidations of RS-8359, a selective and reversible MAO-A inhibitor, and cinchona alkaloids by aldehyde oxidase. Biopharmaceutics & Drug Disposition. ,vol. 27, pp. 133- 139 ,(2006) , 10.1002/BDD.494
TOMIHISA YOKOYAMA, TOSHIO KARUBE, NOBUYOSHI IWATA, Comparative studies of the effects of RS-8359 and safrazine on monoamine oxidase in-vitro and in-vivo in mouse brain. Journal of Pharmacy and Pharmacology. ,vol. 41, pp. 32- 36 ,(2011) , 10.1111/J.2042-7158.1989.TB06324.X
Tetsuo KUNIEDA, Eiji KOBAYASHI, Motokazu TACHIBANA, Hiroshi IKADAI, A genetic linkage map of rat chromosome 9 with a new locus for variant activity of liver aldehyde oxidase. Experimental Animals. ,vol. 48, pp. 43- 45 ,(1999) , 10.1538/EXPANIM.48.43
H. Miura, M. Naoi, D. Nakahara, T. Ohta, T. Nagatsu, Changes in monoamine levels in mouse brain elicited by forced-swimming stress, and the protective effect of a new monoamine oxidase inhibitor, RS-8359. Journal of Neural Transmission. ,vol. 94, pp. 175- 187 ,(1993) , 10.1007/BF01277023
Shigeyuki Kitamura, Kazumi Sugihara, Keiko Nakatani, Shigeru Ohta, Toshinari Oh-Hara, Shin-Ichi Ninomiya, Carol Green, Charles Tyson, Variation of hepatic methotrexate 7-hydroxylase activity in animals and humans. Iubmb Life. ,vol. 48, pp. 607- 611 ,(1999) , 10.1080/713803569
Christine Beedham, Jeffrey J. Miceli, R. Scott Obach, Ziprasidone Metabolism, Aldehyde Oxidase, and Clinical Implications Journal of Clinical Psychopharmacology. ,vol. 23, pp. 229- 232 ,(2003) , 10.1097/01.JCP.0000084028.22282.F2
K. Itoh, M. Yamamura, S. Muramatsu, K. Hoshino, A. Masubuchi, T. Sasaki, Y. Tanaka, Stereospecific oxidation of the (S)-enantiomer of RS-8359, a selective and reversible monoamine oxidase A (MAO-A) inhibitor, by aldehyde oxidase. Xenobiotica. ,vol. 35, pp. 561- 573 ,(2005) , 10.1080/00498250500202106