Strategies for a comprehensive understanding of metabolism by aldehyde oxidase.

摘要: Introduction: Aldehyde oxidase (AO) is a drug-metabolizing molybdo-flavoenzyme with profound species differences in expression and activity toward various substrates. The contribution of this enzyme to the metabolism clearance heterocyclic-containing xenobiotics appears have increased recent years, but has not always been identified prior clinical studies. As result, drug candidates negatively impacted development. Areas covered: This review provides most vitro vivo strategies for metabolism-pharmacokinetic (DMPK) scientist. details approaches confirmation AO as an operable metabolic pathway, estimating fraction total metabolism, identification appropriate surrogate human evaluating safety clinically relevant metabolites. Expert opinion: role new molecules continues emerge, it critical that DMPK scientists updated me...