Maternal preconceptional nutrition leads to variable fat deposition of adult offspring mice (C57BL/6JBom)

摘要: Maternal nutrition during pregnancy or lactation may affect the chance of offspring becoming obese as adults, but little is known about possible role maternal before conception. Here we investigate how variable protein and carbohydrate content diet consumed affects fat deposition mice. Eight week old female mice (C57BL/6JBom) were fed isocaloric low (8.4% protein; LP), standard (21.5% ST) high (44.2% HP) diets. After eight weeks feeding, females mated a laboratory chow (22.5% protein) throughout periods mating, gestation, weaning. Offspring same until 46 days age. Then killed measures dissected deposits taken. Fat was significantly affected by preconceptional effects differed among sexes. Male deposited most when mothers LP diet, whereas ST diet. Our study demonstrates that can have important influence on in