Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study
作者： Tess V. Clendenen , Wenzhen Ge , Karen L. Koenig , Tomas Axelsson , Mengling Liu
DOI: 10.1371/JOURNAL.PONE.0140478
关键词: Genome-wide association study 、 Single-nucleotide polymorphism 、 Endocrinology 、 Vitamin D-binding protein 、 Internal medicine 、 Oncology 、 Breast cancer 、 Vitamin D and neurology 、 Biology 、 Vitamin D3 24-Hydroxylase 、 Calcitriol receptor 、 Nested case-control study
摘要: Genetic polymorphisms in vitamin D metabolism and signaling genes have been inconsistently associated with risk of breast cancer, though few studies examined SNPs D-related other than the receptor (VDR) gene particularly not association retinoid X alpha (RXRA) which may be a key pathway gene. We conducted nested case-control study 734 cases 1435 individually matched controls from population-based prospective cohort study, Northern Sweden Mammary Screening Cohort. Tag functional were genotyped for VDR, cytochrome p450 24A1 (CYP24A1), RXRA genes. also specific four related to (GC/VDBP, CYP2R1, DHCR7, CYP27B1). VDBP regions that circulating 25(OH)D concentration GWAS plasma our (p-trend <0.005). After taking into account false discovery rate, these significantly cancer risk, nor any or haplotypes RXRA, CYP24A1. observed no statistically significant associations between cancer. These results, combined observation this most do support an risk.
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