Theoretical studies on the regulation of anaerobic glycolysis and its influence on oxidative phosphorylation in skeletal muscle

摘要: Abstract It is shown, using the computer model of glycolysis in skeletal muscle developed recently by Lambeth and Kushmerick (Ann. Biomed. Bioenerg, 30 (2001) 19-34) incorporated into oxidative phosphorylation Korzeniewski et al. (Biophys. Chem. 83 that regulation ADP, AMP Pi decidedly insufficient to explain large increase glycolytic flux during transition from rest intensive exercise intact muscle. Computer simulations based on a simple kinetic description ATP H+ production strongly suggests must be directly activated contraction. They also demonstrate inhibition needed transient activation this pathway at onset as well duration time extent initial alkalization after exercise. Finally, it shown supply anaerobic slows down V o 2 kinetics rest-to-work transition.