Presence of retinal pericyte-reactive autoantibodies in diabetic retinopathy patients
作者： Lingjun Zhang , Yan Li , John Payne , Sunil Srivastava , Xingjun Fan
DOI: 10.1038/SREP20341
关键词: Autoantibody 、 Retinal 、 Antigen 、 Complement system 、 Immunology 、 Medicine 、 C4A 、 Pericyte 、 Diabetic retinopathy 、 Immunoglobulin G
摘要: The loss of retinal pericytes (RPCs) is a hallmark early stage diabetic retinopathy (DR), but the mechanism underlying RPC death unclear. Although it was postulated in previous studies using bovine RPCs that autoantibodies against might develop and induce death, unknown whether cell-surface antigens on human exist DR patients, such contribute to damage/loss, if they do, through which mechanism. We screened serum samples from patients controls primary found levels IgGs reactive were significantly higher group than control group. Serum with RPC-reactive IgG induced more severe complement-mediated damage those lower levels. also assessed complement-activation products C3a, C4a C5a these samples, C3a C5a, not C4a, These data provide evidence first time showing can could pericyte complement activation.
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Fatin Awartani, Serum immunoglobulin levels in type 2 diabetes patients with chronic periodontitis. The journal of contemporary dental practice. ,vol. 11, pp. 001- 8 ,(2010) , 10.5005/JCDP-11-3-1
R J Quigg, A E Sneed, B P Morgan, V M Holers, Crry and CD59 regulate complement in rat glomerular epithelial cells and are inhibited by the nephritogenic antibody of passive Heymann nephritis. Journal of Immunology. ,vol. 154, pp. 3437- 3443 ,(1995)
G W Schmid-Schönbein, W Palinski, S Schröder, Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy. American Journal of Pathology. ,vol. 139, pp. 81- 100 ,(1991)
Lingling Du, Timothy S. Kern, Hongyan Ge, Haitao Liu, Linan Guan, Pei Tian, Ping Liu, Sheng Su, Leukocytes from diabetic patients kill retinal endothelial cells: effects of berberine. Molecular Vision. ,vol. 19, pp. 2092- 2105 ,(2013)
J.E. Salmon, G. Girardi, The Role of Complement in the Antiphospholipid Syndrome Current directions in autoimmunity. ,vol. 7, pp. 133- 148 ,(2004) , 10.1159/000075690
R. C. Nayak, C. D. Agardh, M. G. K. Kwok, H. Stjernquist, P. J. Farthing-Nayak, E. Agardh, Circulating anti-pericyte autoantibodies are present in Type 2 diabetic patients and are associated with non-proliferative retinopathy Diabetologia. ,vol. 46, pp. 511- 513 ,(2003) , 10.1007/S00125-003-1057-0
Per Lindahl, Bengt R Johansson, Per Leveen, Christer Betsholtz, Pericyte loss and microaneurysm formation in PDGF-B-deficient mice Science. ,vol. 277, pp. 242- 245 ,(1997) , 10.1126/SCIENCE.277.5323.242
ElinorD.U. Powell, RichardA. Field, DIABETIC RETINOPATHY AND RHEUMATOID ARTHRITIS. The Lancet. ,vol. 284, pp. 17- 18 ,(1964) , 10.1016/S0140-6736(64)90008-X
MauroS. Sandrin, Ian F. C. Mckenzie, Gal alpha (1,3)Gal, the major xenoantigen(s) recognised in pigs by human natural antibodies. Immunological Reviews. ,vol. 141, pp. 169- 190 ,(1994) , 10.1111/J.1600-065X.1994.TB00877.X
Yan Li, Feng Lin, Mesenchymal stem cells are injured by complement after their contact with serum Blood. ,vol. 120, pp. 3436- 3443 ,(2012) , 10.1182/BLOOD-2012-03-420612