Plasma Exosomes Contribute to Microvascular Damage in Diabetic Retinopathy by Activating the Classical Complement Pathway.

摘要: Diabetic retinopathy (DR) is a microvascular complication of diabetes and the leading cause vision loss in working-age adults. Recent studies have implicated complement system as player development vascular damage progression DR. However, role activation DR are not well understood. Exosomes, small vesicles that secreted into extracellular environment, cargo proteins plasma, suggesting they can participate causing associated with We demonstrate IgG-laden exosomes plasma activate classical pathway quantity these increased diabetes. Moreover, we show lack IgG diabetic mice results reduction retinal damage. The this study by could contribute to