Recent advances of exosomes in immune-mediated eye diseases.

摘要: Exosomes, nanosized extracellular vesicles of 30–150 nm, are shed by almost all cell types. Bearing proteins, lipids, RNAs, and DNAs, exosomes have emerged as vital biological mediators in cell-to-cell communication, affecting a plethora physiological pathological processes. Particularly, mounting evidence indicates that immunologically active can regulate both innate adaptive immune responses. Herein, we review recent advances the research several immune-mediated eye diseases, including Sjogren’s syndrome (SS) dry eye, corneal allograft rejection, autoimmune uveitis, age-related macular degeneration (AMD). Additionally, discuss potential novel biomarkers drug delivery for diagnosis treatment diseases.