Structure, mechanism, and evolution of the mRNA capping apparatus.
作者： Stewart Shuman
DOI: 10.1016/S0079-6603(00)66025-7
关键词: RNA triphosphatase 、 Biochemistry 、 Biology 、 Capping enzyme 、 Gene 、 Enzyme 、 Mutagenesis 、 Complementary DNA 、 Guanylyltransferase 、 RNA capping
摘要: Publisher Summary This chapter discusses the recent progress, concerning mechanism of cap synthesis, by fungal and mammalian enzymes. Viral capping enzymes are discussed to extent that their study illuminates mechanistic features, shared cellular counterparts. The structural features required for guanylyltransferase, triphosphatase, methyltransferase activities. It also describes how these conserved in evolution. essential elements illuminate reaction mechanisms described briefly this chapter. emphasizes importance structure determinations clarifying models catalysis, opening new lines biochemical investigation, illuminating surprising complexities seemingly “simple” enzymatic steps. concludes with following: (i) cloning genes complementary DNA (cDNA) encoding cap-forming from a wide variety sources; (ii) delineation functional domains catalytically amino acid side chains mutagenesis; (iii) application X-ray crystallography determine physical organizations component activities diverged during evolution
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