Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer???s Disease Models
作者： C.Y. Daniel Lee , Anthony Daggett , Xiaofeng Gu , Lu-Lin Jiang , Peter Langfelder
DOI: 10.1016/J.NEURON.2018.02.002
关键词: Cancer research 、 Microglia 、 Phenotype 、 Transcriptome 、 Phagocytosis 、 TREM2 、 Neuroinflammation 、 Gene dosage 、 Downregulation and upregulation 、 Biology
摘要: … expressing human TREM2 (BAC-TREM2) in microglia. We found that elevated TREM2 expression … We used a human TREM2 BAC for several reasons: first, human TREM2 and murine …
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