摘要: Partial loss-of-function variants in the TREM2 immune receptor are associated with increased risk for Alzheimer's disease (AD) and other forms of neurodegenerative disease, but molecular bases these connections unknown. Three new structures WT R47H mutant immunoglobulin-like (Ig-like) domain now reveal that R47 functions to correctly position elements ligand-binding surface. Intriguingly, authors also demonstrate a disruption oligomerization by mutation, suggesting role ligand-induced clustering signaling resultant plaque clearance.
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