Phagocytized corpora amylacea as a histological hallmark of astrocytic injury in neuromyelitis optica

作者: Aya Suzuki , Hideaki Yokoo , Akiyoshi Kakita , Hitoshi Takahashi , Yasuo Harigaya

DOI: 10.1111/J.1440-1789.2012.01299.X

关键词: Neuromyelitis opticaCorpora amylaceaPathologyOptic nerveMyelinAutoantibodySpinal cordImmunologyPathophysiologyMultiple sclerosisMedicine

摘要: Neuromyelitis optica (NMO) is an inflammatory demyelinating and necrotizing disorder of the CNS that mainly affects optic nerve spinal cord. The etiology still uncertain; however, discovery serum anti-aquaporin-4 (AQP4) autoantibody becoming center attention, a new hypothesis emerging NMO essentially astrocytopathy provoked by this autoantibody. In study, we focused on corpora amylacea (CA), glycoproteinaceous inclusions in astrocytic processes. We examined 57 lesions nine cases spectrum disorder, demonstrated CA were phagocytized macrophages 42 (74%) eight cases, while figures not seen unaffected areas. Phagocytized frequently encountered early-phase retaining myelin structures, fewer or none found chronic destructive lesions. Moreover, significantly smaller diameter than intact ones, decreased absent most assessed. These findings suggest following pathophysiological process: astrocytes are affected at early phase NMO, expelled from finally leading to clearance. A figure subsequent loss can be histological hallmark injury NMO.

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