Curcumin: A Potent Modulator of Multiple Enzymes in Multiple Cancers.

摘要: Curcumin (diferuloylmethane) is the biphenolic active compound of turmeric. has been used for hundreds years to treat various ailments. reported exert numerous pharmacological effects by modulating multiple molecular targets including those involved in pathogenesis cancer. Cancer characterized as dysregulation cell signaling pathways through gradual alteration regulatory proteins and gene mutation. a highly pleiotropic molecule that modulates several intracellular The activities curcumin have attributed its novel structure. Based on β-diketone moiety, exists keto-enol tautomers, this tautomerism favors interaction binding with wide range enzymes. Several studies shown modulation enzymes including, LOX, COX-2, XO, proteasomes, Ca(2+)-ATPase sarcoplasmic reticulum, MMPs, HAT, HDAC, DNMT1, DNA polymerase λ, ribonucleases, GloI, protein kinases (PKA, PKB, PKC, v-Src, GSK-3β, ErbB2), reductases (TrxR1, AR), GSH, ICDHs, peroxidases (Prx1, Prx2, Prx6) treatment curcumin. Various biophysical analyses reported, which shows underlying terms affinities. current chapter describes how binds Published clinical trial cancer management will also be discussed.