Stevens‐Johnson syndrome and toxic epidermal necrolysis: a retrospective descriptive study

摘要: BACKGROUND Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare potentially life-threatening mucocutaneous reactions. Given their rarity, limited cohort studies have been done. The aim of this study is to evaluate compare the demographics, etiology, management, clinical laboratory characteristics, complications, outcome SJS/TEN patients seen by inpatient dermatology service at University Puerto Rico. METHODS A retrospective review 30 cases with identified diagnosis SJS, overlap SJS/TEN, or TEN who were consulted Dermatology Department Rico from 2006 2017. RESULTS total 24 adult six pediatric reviewed. Females predominant a female male ratio 1.3 : 1. most frequent offending drugs antibiotics (56.7%), anticonvulsants (23.3%), nonsteroidal anti-inflammatory (NSAIDs) (16.7%) antibiotic being trimethoprim/sulfamethoxazole (23.3%). Seventy percent experienced least one complication, often infectious etiology (80.1%). During hospital course, 73% received pharmacologic therapy (23% IVIG alone, 17% steroids 33% both) versus 27% which only supportive care. Mortality rate in was 13.8%. When comparing SCORTEN day admission, deceased had mean 1 4.0, while survivors an average 1.54 (P < 0.001). CONCLUSION Antibiotics followed frequently within study.