Organization of the ζ-α genes in Chinese
作者： Vivian Chan , T. K. Chan , M. Y. Cheng , Y. W. Kan , D. Todd
DOI: 10.1111/J.1365-2141.1986.TB07577.X
关键词: Globin 、 Hypervariable region 、 Thalassemia 、 Hemoglobinopathy 、 Beta-thalassaemia 、 Biology 、 Genetics 、 Alpha (ethology) 、 Mutation 、 Gene
摘要: Analysis of alpha and zeta genes in 101 healthy normals hospitalized patients with non-haematological diseases revealed a 3% incidence thalassaemia the local Chinese population Hong Kong. Triple were found only one person while triple more prevalent, occurring 13 subjects. Studies 28 unselected Hb H disease indicated predominance rightward gene deletion. The extent deletion homozygous 1 was at least 18.1 kb, beginning from BamH I site 3' to includes psi alpha, 2 genes. Nineteen 20 chromosomes bearing had identical zeta-intergenic hypervariable region suggesting common origin this mutation. co-inheritance beta subjects 8%, but did not ameliorate clinical features those thalassaemia.
core.ac.uk
hku.hk
sci-hub.se 参考文章(22)
P. Winichagoon, D.R. Higgs, S.E. Goodbourn, J.B. Clegg, D.J. Weatherall, P. Wasi, The molecular basis of alpha-thalassaemia in Thailand. The EMBO Journal. ,vol. 3, pp. 1813- 1818 ,(1984) , 10.1002/J.1460-2075.1984.TB02051.X
Michel Goossens, Yuet Yai Kan, [49] DNA analysis in the diagnosis of hemoglobin disorders Methods in Enzymology. ,vol. 76, pp. 805- 817 ,(1981) , 10.1016/0076-6879(81)76159-7
V Chan, TK Chan, ST Liang, A Ghosh, YW Kan, D Todd, Hydrops fetalis due to an unusual form of Hb H disease Blood. ,vol. 66, pp. 224- 228 ,(1985) , 10.1182/BLOOD.V66.1.224.224
D. R. Higgs, J. M. Old, L. Pressley, J. B. Clegg, D. J. Weatherall, A novel alpha-globin gene arrangement in man. Nature. ,vol. 284, pp. 632- 635 ,(1980) , 10.1038/284632A0
M. A. Melis, R. Galanello, A. Cao, Alpha globin gene analysis in a Sardinian family with interacting alpha and beta thalassaemia genes British Journal of Haematology. ,vol. 53, pp. 667- 671 ,(1983) , 10.1111/J.1365-2141.1983.TB07318.X
Michel Goossens, Kathleen Y. Lee, Stephen A. Liebhaber, Yuet Wai Kan, Globin structural mutant α 125Leu-->Pro is a novel cause of α-thalassaemia Nature. ,vol. 296, pp. 864- 865 ,(1982) , 10.1038/296864A0
L. Pressley, D. R. Higgs, J. B. Clegg, D. J. Weatherall, Gene deletions in alpha thalassemia prove that the 5' zeta locus is functional. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 77, pp. 3586- 3589 ,(1980) , 10.1073/PNAS.77.6.3586
Y.-T. Zeng, S.-Z. Huang, α-GLOBIN GENE ORGANISATION AND PRENATAL DIAGNOSIS OF α-THALASSAEMIA IN CHINESE The Lancet. ,vol. 325, pp. 304- 307 ,(1985) , 10.1016/S0140-6736(85)91081-5
Joyce Lauer, Che-Kun James Shen, Tom Maniatis, The chromosomal arrangement of human α-like globin genes: Sequence homology and α-globin gene deletions Cell. ,vol. 20, pp. 119- 130 ,(1980) , 10.1016/0092-8674(80)90240-8
D. R. Higgs, L. Pressley, J. B. Clegg, D. J. Weatherall, S. Higgs, P. Carey, G. R. Serjeant, Detection of alpha thalassaemia in Negro infants. British Journal of Haematology. ,vol. 46, pp. 39- 46 ,(2008) , 10.1111/J.1365-2141.1980.TB05933.X