Clinical treatment of cutaneous leishmaniasis in dogs with furazolidone and domperidone.
作者： Stela Rechinelli Passos , Tadeu de Azevedo Rodrigues , Ana Paula Madureira , Rodolfo Cordeiro Giunchetti , Marcos Santos Zanini
DOI: 10.1016/J.IJANTIMICAG.2014.07.011
关键词: Internal medicine 、 Leishmania 、 Furazolidone 、 Domperidone 、 Zoonosis 、 Leishmania braziliensis 、 Lesion 、 Pathology 、 Parasite hosting 、 Cutaneous leishmaniasis 、 Biology 、 Gastroenterology
摘要: a b s t r c Cutaneous leishmaniasis (CL) is zoonosis and public health problem in countries of subtropical Amer- ica. The aim this study was to investigate the efficacy furazolidone domperidone treatment dogs naturally infected with Leishmania (Viannia) braziliensis. Infection confirmed by PCR parasite culture tissue collected from skin scrapings lesion borders dogs. Naturally animals were divided into control (n = 4) 8) groups. group administered for 21 days interspersed 10 oral gavage. Dogs that showed no healing during period same cycle up 93 days. Among eight treated animals, seven clinically cured without recurrence lesions 12- month period. However, healing, positive L. (V.) braziliensis PCR; growth protozoan NNN-LIT medium occurred until end follow-up. These results suggest effective epithelialisation clinical CL caused
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