Zolpidem modulates GABAA receptor function in subthalamic nucleus
作者： Lei Chen , Jun-Xia Xie , Kam-Shuen Fung , Wing-Ho Yung
DOI: 10.1016/J.NEURES.2007.02.002
关键词: Zolpidem 、 Benzodiazepine 、 Pharmacology 、 Indirect pathway of movement 、 Subthalamic nucleus 、 Flumazenil 、 Inhibitory postsynaptic potential 、 Basal ganglia 、 GABAA receptor 、 Chemistry 、 Neuroscience
摘要: The subthalamic nucleus occupies a position in the indirect pathway of basal ganglia circuit, which plays an important role movement regulation. Zolpidem is imidazopyridine agonist with high affinity on benzodiazepine site GABA(A) receptors containing alpha 1 subunit. Recently, zolpidem has been reported to be useful treating subgroups parkinsonian patients. A density binding sites shown rat nucleus. To further investigate modulation receptor-mediated inhibitory synaptic current nucleus, whole-cell patch clamp recordings were used present study. at 100nM significantly prolonged decay time and rise miniature postsynaptic currents, no effect amplitude frequency. antagonist flumazenil could completely block potentiation induced by zolpidem, confirming specificity site. At concentration microM, increased time, frequency currents. In behaving rats, unilateral microinjection into significant contralateral rotation. findings provide rationale for investigations its potential treatment Parkinson's disease.
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