Vinyl and Aryl Halides

摘要: The development of synthetic methodology that will enable the preparation vinyl fluorides, bromides, and iodides has become an important theme in halide chemistry. This is a consequence plethora natural products compounds biological interest possess one or more alkenyl groups, usually as geometrical isomer. Thus, single isomers bromides because these are frequently used substrates for cross-coupling reactions (e.g., Suzuki Stille reactions), yielding alkenes, dienes, higher homologs with defined stereochemistry around each bond. isosteric replacement hydrogen by fluorine common synthesis analogs biologically active modification properties imparted introduction fluorine. Consequently fluoride molecules groups received considerable attention. Aryl halides form building blocks many aromatic halogens into electron-rich electron-deficient rings attracted interest. useful fluorine, noted above, compounds.