Rho-ROCK Signaling in Normal Physiology and as a Key Player in Shaping the Tumor Microenvironment.
作者： Sean Porazinski , Ashleigh Parkin , Marina Pajic
DOI: 10.1007/978-3-030-35582-1_6
关键词: Tumor microenvironment 、 Morphogenesis 、 Key (cryptography) 、 Pancreatic cancer 、 Stromal cell 、 Targeted therapy 、 Extracellular matrix 、 Neuroscience 、 Rho rock 、 Biology
摘要: The Rho-ROCK signaling network has a range of specialized functions key biological importance, including control essential developmental processes such as morphogenesis and physiological homeostasis, immunity, wound healing. Deregulation actively contributes to multiple pathological conditions, plays major role in cancer development progression. This dynamic is critical modulating the intricate communication between tumor cells, surrounding diverse stromal cells matrix, shaping ever-changing microenvironment aggressive tumors. In this chapter, we overview complex regulation axis, its health disease, analyze progress made with approaches targeting pathway for therapeutic benefit. Finally, conclude by outlining likely future trends questions field research, particular within microenvironment.
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