TCF-1 limits the formation of Tc17 cells via repression of the MAF–RORγt axis

作者: Lisa A. Mielke , Yang Liao , Ella Bridie Clemens , Matthew A. Firth , Brigette Duckworth

DOI: 10.1084/JEM.20181778

关键词: Interleukin 17T cell differentiationT cellCell biologyCD8Transcription factorCell growthProto-Oncogene Proteins c-mafInterferonChemistry

摘要: Interleukin (IL)-17-producing CD8+ T (Tc17) cells have emerged as key players in host-microbiota interactions, infection, and cancer. The factors that drive their development, contrast to interferon (IFN)-γ-producing effector cells, are not clear. Here we demonstrate the transcription factor TCF-1 (Tcf7) regulates cell fate decisions double-positive (DP) thymocytes through sequential suppression of MAF RORγt, parallel with TCF-1-driven modulation chromatin state. Ablation resulted enhanced Tc17 development exposed a gene set signature tissue repair lipid metabolism, which was distinct from other subsets. IL-17-producing isolated healthy humans were also CD8+IL-17- enriched pathways driven by RORγt Overall, our study reveals how exerts central control differentiation thymus normally repressing promoting an outcome.

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