T Cell Factor-1 Negatively Regulates Expression of IL-17 Family of Cytokines and Protects Mice from Experimental Autoimmune Encephalomyelitis

摘要: Activated CD4 T cells are associated with protective immunity and autoimmunity. The manner in which the inflammatory potential of resultant autoimmunity is restrained poorly understood. In this article, we demonstrate that cell factor-1 (TCF1) negatively regulates expression IL-17 related cytokines activated cells. We show TCF1 does not affect cytokine signals transcription factors have been shown to regulate Th17 differentiation. Instead, expression, part, by binding regulatory regions Il17 gene. Moreover, TCF1-deficient express higher levels IL-7Rα, potentially promotes their survival expansion vivo. Accordingly, mice hyperresponsive experimental autoimmune encephalomyelitis. Thus, TCF1, a constitutively expressed cell-specific factor, critical negative regulator TCR-activated