Antigalactocerebroside serum demyelinates optic nerve in vivo
作者： Robert C. Sergott , Mark J. Brown , Donald H. Silberberg , Robert P. Lisak
DOI: 10.1016/0022-510X(84)90177-1
关键词: Pathology 、 Guinea pig 、 Central nervous system 、 Galactocerebroside 、 Myelin 、 Biology 、 Optic nerve 、 Antiserum 、 Immunology 、 In vivo 、 Oligodendrocyte
摘要: Antiserum to the myelin lipid galactocerebroside (GalC) causes rapidly progressive focal demyelination when injected into guinea pig optic nerves. The capacity of anti-GalC induce central nervous system is complement-dependent, and demyelinating activity present in immunoglobulin fraction serum. Demyelination appears result from primary damage oligodendrocytes.
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