Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determines size and structure of demyelinated lesions.

摘要: The effect of a circulating monoclonal antibody recognizing an antigen located on the surface myelin sheaths (myelin/oligodendroglia glycoprotein, MOG) clinical and histopathological expression experimental allergic encephalomyelitis (EAE) was tested in model EAE passively transferred by monospecific T lymphocytes. Intravenous injection anti-MOG at onset disease massively augmented impairment as well primary demyelination. structure CNS lesions depended balance between encephalitogenic cells antibody: when induced with high numbers cells, resulted ubiquitous perivenous demyelination spinal cord medulla oblongata. On contrary, focal confluent demyelinated were observed animals injected low (even few 104) antibody. Our studies, thus, indicate that formation inflammatory demyelinating may be due to synergistic action cellular humoral immune mechanisms.