Advanced age increases chromosome structural abnormalities in human spermatozoa.

摘要: This study explores the relationship between sperm structural aberrations and age by using a multicolor multichromosome FISH strategy that provides information on incidence of duplications deletions all autosomes. ToTelvysion kit (Abbott Molecular, Abbott Park, IL, USA) with telomere-specific probes was used. We investigated 10 male donors aged from 23 to 74 years old. The were divided into two groups according age, cohort five individuals younger than 40 older 60 years. goal this determine (1) donor frequency type chromosome abnormalities (2) chromosomes more frequently involved in aberrations. found patients had higher rate (6.6%) compared (4.9%). Although both seen men, our findings demonstrate presence an excess versus at ratio 2 1. distribution not linear along chromosomes, although trend toward larger observed. work is first addressing frequencies autosomes single assay thus making contribution clarification amount origin damage present human spermatozoa relation age.