An analysis of human sperm chromosome breakpoints.

摘要: Sperm chromosome analysis of 19 sperm donors with either normal or balanced karyotypes was carried out in order to explore the nature structural aberrations. A total 2,389 cells (range 36-298/donor) were karyotyped after vitro penetration hamster eggs. The median percentage aberrations 9.3% (SD +/- 4.7; range 0%-17.8%), a 247 breakpoints, which 220 could be characterized fully. Two sets studied two different centers: center 1 (United States) and 2 (Spain). frequencies nonrejoined rejoined chromosome-type very similar between 2: 83.6% 10.0%, 75.0% 10.3%, respectively. Chromatid-type more frequent (14.7%) than (6.4%) (P = .037). Chromosome 4 had less expected number breakpoints < .001). positive significant correlation found reported this study sites de novo rearrangements detected at prenatal diagnosis literature .0001).