Reproductive functions of the ageing male

摘要: Delayed childbearing is a common phenomenon in industrialized countries. This review focuses on age-associated alterations of male fertility and genetic risks. Semen volume, sperm motility morphology decrease with age, whereas the data concerning concentration are conflicting. The age-related changes semen parameters reflect histological modifications which found to varying degrees individual testes. Men aged > 40 years contribute reduced fecundity couple, especially when female partner also advanced age. Because relatively few children born older fathers diseases rare, there little statistical power supporting an association offspring advancing paternal Nevertheless, autosomal dominant some complex aetiology, such as schizophrenia, associated single point mutations responsible for achondroplasia Apert’s syndrome, two diseases, increase man’s In case syndrome this believed be due pre-meiotic selection mutant spermatogonia. Although structural chromosome anomalies disomies certain chromosomes age is, exception trisomy 21, not numerical or de novo chromosomal aberrations newborns. However, even if risk progeny from slightly increased, low.