Biochemical epidemiology of gallbladder cancer

摘要: To evaluate the a priori hypotheses that an increased level of glyco and tauro lithocholic acid, perhaps because decreased capacity for hepatic sulfation, contributed to biochemical epidemiology gallbladder cancer, case-control study was undertaken at four hospitals in La Paz, Bolivia, one hospital Mexico City, Mexico. Eighty-four cases with newly diagnosed histologically confirmed cancer were compared 264 controls cholelithiasis or choledocholithiasis absence 126 normal biliary tracts. All subjects undergoing abdominal surgery. Interview data collected all subjects, as well blood, bile, gallstone specimens when feasible. Sera analyzed carcinoembryonic antigen, cholesterol concentration, total bile acids. Bile antigen; concentration salts; cholesterol; phospholipids; glycine taurine conjugates cholic, ursodeoxycholic, chenodeoxycholic, deoxycholic, lithocholates; sulfoglycolithocholate; sulfotaurolithocholate. Gallstone percentage content, calcium bilirubinate carbonate content. Serum acids versus two control groups (median 11.7 nmol/mL vs. 9.3 stone 8.2 nmol/L nonstone controls, P < = .02 each pairwise comparison). Biliary markedly 3.98 micromol/mL 33.09 micromol/mL, 154.0 micromol/L, respectively, .0001 comparison), even after excluding those serum bilirubin higher than 2.0 mg/dL. lower 1.70 4.90 16.81 micromol/ mL, .02), phospholipids 2.97 6.26 52.69 .1 .0004, respectively). Contrary our hypothesis, there no difference between either group their concentrations lithocholate, proportion which sulfated, nonsulfated lithocholate. However, had ursodeoxycholate (UDC) (P .004 both groups), especially glycoursodeoxycholate .001 groups). A previously published suggestion size differed not confirmed. In conclusion, from stones tracts biochemistries. These findings may be reflection disease process, provide useful clues its pathogenesis.