Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane.

摘要: Sulforaphane is a promising agent under preclinical evaluation in many models of disease prevention. This bioactive phytochemical affects molecular targets cellular and animal models; however, amongst the most sensitive Keap1, key sensor for adaptive stress response system regulated through transcription factor Nrf2. Keap1 sulfhydryl-rich protein that represses Nrf2 signaling by facilitating polyubiquitination Nrf2, thereby enabling its subsequent proteasomal degradation. Interaction sulforaphane with disrupts this function allows nuclear accumulation activation transcriptional program. Enhanced target genes provokes strong cytoprotective enhances resistance to carcinogenesis other diseases mediated exposures electrophiles oxidants. Clinical has been largely conducted utilizing preparations broccoli or sprouts rich either precursor form plants, stable β-thioglucose conjugate termed glucoraphanin. We have series clinical trials Qidong, China, region where food- air-borne carcinogens considerable, evaluate suitability sprout beverages, glucoraphanin both, their bioavailability, tolerability, pharmacodynamic action population-based interventions. Results from these indicate interventions well characterized may enhance detoxication aflatoxins toxins, which turn attenuate associated health risks, including cancer, exposed individuals.